This volume presents a unique comparative treatment of the role oxidative stress plays in vertebrates and invertebrates in multiple organ systems with regards to cell death, development, aging, and human diseases, and anti-oxidant therapy

Part 1. Oxidative stress in vertebrates 1. Generation of reactive oxygen species in brain 2. Free radicals, signal transduction, and human disease 3. Oxidative stress and its biochemical consequences 4. Oxidative stress in Kainic acid neurotoxicity 5. Survival strategy and disease pathogenesis according to Nrf2-small Maf heterodimer 6. Caloric restriction and oxidatvie stress 7. Pathogenesis of neurodegenerative diseases 8. Neurosteroids of Oxidative stress-mediated injury in Alzheimer disease 9. Oxidative stress in adult neurogenesis and in the pathogenesis of Alzheimer disease 10. Oxidative stress and Parkinson disease 11. Oxidative stress in cardiovascular disease 12. Oxidative stress and aging 13. Oxidative stress-Mediated signaling pathways 14. Selenoproteins in cellular redox regulation and signaling 15. Antioxidant therapy and its effectiveness 16. The protective role of grape seed polyphenols against Oxidative stress in treating neurodegenerative disease 17. Pharmacological and therapeutic properties of propils 18. Endocrine control of Oxidative stress in Insects 19. Oxidative stress in the airway system of fruit fly 20. Molecular mechanisms of antioxidant protective processes in honeybee 21. Molecular basis of Iron-induced Oxidative stress in the honeybee brain 22. Modulation of Oxidative stress by Keap1/Nrf2 signaling in Drosophila 23. Orchestration of Oxidative stress responses 24. The protective role of sestrins against chronic TOR activation and Oxidative stress 25. Current advances in the studies of Oxidative stress and age-related memory impairment in C.elegans 26. Oxidative challenge and redox sensing in Mollusks 27. Perspective and directions for future studies